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Ferguson Ford W.R. Ford Genazzani A.A. Genazzani Gergely F.V. Gergely Gubitz A.K. Gubitz Henderson R.M. Henderson Hiley C.R. Hiley Hinchliffe K.A. Hinchliffe Hladky S.B. Hladky Humphrey P.P.A. Humphrey Irvine R.F. Irvine Kidd E.J. Kidd Koenig J.A. Koenig MacVinish L.J. MacVinish Marchant J.S. Marchant Matthews E.K. Matthews McNaughton P.A. McNaughton Michel A.D. Michel Morton A.J. Morton Murphy K.P.S.J. Murphy Murrell-Lagnado R.D. Murrell-Lagnado Perkins T.D.J. Perkins Richardson P.J. Richardson Sellers L.A. Sellers Smith P.A. Smith Taylor C.W. Taylor Thomas P. Thomas Thorn P. Thorn Thornton S. Thornton van Veen H.W. van Veen Waring M.J. Waring White R White Young J.M. Young BLANK J.L. BLANK BOARDER MR BOARDER BOYLE JP BOYLE BREW H BREW BRUNSKILL N.J. BRUNSKILL CAVIERES J.D. CAVIERES CHALLISS R.A.J. CHALLISS DART C. DART DAVIES N.W. DAVIES DONALDSON LF DONALDSON EVANS R.J. EVANS FORSYTHE I.D. FORSYTHE GRUBB B.D. GRUBB MACONOCHIE DJ MACONOCHIE MITCHESON J. MITCHESON NAHORSKI S.R. NAHORSKI NICOTERA PL NICOTERA SEWARD E.P. SEWARD STANDEN N.B. STANDEN STANFIELD P.R. STANFIELD TOBIN A.B. TOBIN WILLARS G.B. WILLARS Back DJ Back Breckenridge AM Breckenridge Coker SJ Coker Coleman JW Coleman Edwards IG Edwards Haycox AR Haycox Khoo SH Khoo Kitteringham NR Kitteringham Naisbitt DJ Naisbitt Park BK Park Pirmohamed M Pirmohamed Walley TJ Walley Ward SA Ward Winstanley PA Winstanley Ahluwalia A Ahluwalia Anggard E Anggard Annenkov A E Annenkov Banerjee S Banerjee Barakat K Barakat Benjamin N Benjamin Bishop-Bailey D Bishop-Bailey Blake D R Blake Born G V R Born Carrier M J Carrier Caulfield M J Caulfield Chan W L Chan Chatterjee P K Chatterjee Chernajovsky Y Chernajovsky Colville-Nash P R Colville-Nash Corder R Corder Croxtall J D Croxtall D'Cruz D D'Cruz Dayan T Dayan Flower R J Flower Forte P Forte Getting S J Getting Gilroy D W Gilroy Gould D J Gould Goulding N J Goulding Grootveld M Grootveld Johnston A Johnston Kabouridis P Kabouridis Kengatharan M Kengatharan Kidd B L Kidd La M La Laight D W Laight Lobo M D Lobo MacCallum P K MacCallum MacIntyre I MacIntyre McDonald A McDonald Mcknight G M Mcknight Mclean P G Mclean Mills P G Mills Morris CJ Morris Munroe P B Munroe Nathan A W Nathan Nissim A Nissim O'Byrne S O'Byrne Paine A J Paine Perrett D Perrett Perretti M Perretti Powell C J Powell Thiemermann C Thiemermann Timmis A D Timmis Tomlinson D R Tomlinson Vane J Vane Warner T D Warner Whittle B J Whittle Willis D Willis Willoughby D A Willoughby Winyard P G Winyard Yaqoob M T Yaqoob Zacharowski K Zacharowski Zhang Z Zhang Assem E.S.K. Assem Brown D.A. Brown Buckley M.J. Buckley Carter T.D. Carter Colquhoun D. Colquhoun Cull-Candy S.G. Cull-Candy Dickenson A.H. Dickenson Dolphin A.C. Dolphin Fitzgerald E.M. Fitzgerald Foreman J.C. Foreman Garthwaite J. Garthwaite Gibb A.J. Gibb Jacobs M. Jacobs Jenkinson D.H. Jenkinson Kramer I.M. Kramer Marshall I. Marshall Mathie A. Mathie Millar N.S. Millar Moss G.W.J. Moss Moss S.J. Moss Nurrish S. Nurrish Pitcher J.A. Pitcher Ramage A.G. Ramage Rang H.P. Rang Schoepfer R. Schoepfer Sihra T.S. Sihra Stanford S.C. Stanford Stocker M. Stocker Webster R. Webster Willis D. Willis BEVAN MD BEVAN BOLAM PB BOLAM BRADING AF BRADING BRIDDON SJ BRIDDON BUHL E BUHL CAPOGNA M CAPOGNA CHURCHILL GC CHURCHILL COLEMAN MP COLEMAN CUNNANE TC CUNNANE EMPTAGE NJ EMPTAGE EVANS AM EVANS GABBOTT PLA GABBOTT GALIONE A GALIONE GIBBINS JM GIBBINS GILL EW GILL GREENE JRT GREENE GREENFIELD SA GREENFIELD HOPE DB HOPE JONES RSG JONES KOZLOWSKI RZ KOZLOWSKI MCILHINNEY RAJ MCILHINNEY NAGY Z NAGY PATEL S PATEL PAULSEN OKH PAULSEN PERRY VH PERRY POMPEO F POMPEO ROEPER J ROEPER SANTORO B SANTORO SHARP T SHARP SIM E SIM SMITH AD SMITH SOMOGYI P SOMOGYI TERRAR DA TERRAR TOTTERDELL S TOTTERDELL WATSON SP WATSON Allsopp T Allsopp Antoni FA Antoni Arbuthnott GW Arbuthnott Davies CH Davies de Hoz L de Hoz Donaldson IML Donaldson Fink G Fink Finlayson K Finlayson Grant SGN Grant Harmar AJ Harmar Kelly JS Kelly Kelly PAT Kelly Larkman PM Larkman Marston H Marston Martin SJ Martin McQueen DS McQueen Morris RGM Morris Olverman HJ Olverman Ribchester RR Ribchester Sandin JSBE Sandin Sharkey J Sharkey Shen S Shen Skehel PA Skehel Wood ER Wood Wyllie DJA Wyllie 1998 H-0060 Pulmonary tuberculosis in Harare, Zimbabwe: analysis by spoligotyping Heyderman RS Roberts P Ushewokunze S 1999 H-0060 Spoligotyping in Molecular epidemiology of Tuberculosis in Ghana Lawn SD Afful B Acheampong JW 1999 H-0060 Genotypic analysis of Mycobacterium tuberculosis from medieval human remains Taylor GM Legge AJ Shaw RJ 1997 H-0060 Differentiation of Mycobacterium tuberculosis Isolates by Spoligotyping and IS6110 Restriction Fragment Length Polymorphism Saunders NA van Embden JDA Young DB 1996 H-0060 The preparation of 4-substituted pyrilium salts and their use in dienal synthesis Charoenying P McKerrecher D Taylor RJK 2000 H-0060 A clean and efficient synthesis of 5-(2'-fluoro-2',3'-dimethylbutanyl-3'-yl) substituted 1,2,4-oxadiazoles using silver tetrafluoroborate as a fluorodesulfurization reagent Morgan DT Smalley RK 2000 H-0060 A one-pot Aza-Wittig based solution and polymer supported route to amines Bevan MJ Loukou C Patel SD 2000 H-0060 A thiazine-S-oxide, Staudinger/Aza-Wittig based synthesis of benzodiazepines and benzothiadiazeoines Anwar B Grimsey P Krajniewski M 2000 H-0060 Synthesis of sulphated acrylic polymers and their evaluation as inhibitors of basic fibroblast growth factor dependent cell growth Adnett JB Hay JN Niederst C 1999 H-0060 The use of proteases as prognostic markers for the healing of venous leg ulcers Noble J Eagle M 1996 H-0060 Inhibition of Angiogenesis and murine tumour growth by laminarin sulphate Paper DH Donaldson J Vogl H 1998 H-0060 Wound fluid from venous leg ulcers degrades plasminogen and reduces plasmin generation by keratinocytes Starkey S Coad J 1996 H-0060 An exploration of the structure-activity relationships of 4-aminoquinolones: Novel antimalarials with activity in vivo Dascombe MJ Carr P North SE 1996 H-0060 An inhibitor of the sodium pump obtained from human placenta Hilton PJ White RW Lord GA 1998 H-0060 Mechanism of formation of benzene-2-thiol Isaccs NS Hilton MJ Coulson M 1998 H-0060 Novel aryl-bis-quinolones with antimalarial activity in vivo Dascombe MJ Carr PJ Merette SAM 1999 H-0060 CB1 cannabinoid receptor-mediated activation of K+ current in DDT1 MF-2 cells is entirely dependent on the presence of extracellular Ca2+ Begg M Nelemans SA 1999 H-0060 Reactive oxygen species generation by non-immunological mast cell activation: modulation by the synthetic cannabinoid CP55,940 Brooks A C Gustafsson F Whelan C J 1998 H-0060 Comparison of the effects of drugs on hyperexcitability induced in hippocampal slices by withdrawal from chronic ethanol consumption Bailey C P Little H J 1998 H-0060 Chronic ethanol administration alters neuronal activity in VTA neurones after cessation of withdrawal hyperexcitability Bailey C P Manley S J Watson 1999 H-0060 Reactive oxygen species generation and histamine release by activated mast cells: modulation by nitric oxide synthase inhibition Brooks A C Purcell W M 1999 H-0060 A comparison of the inhibitory effects of budesonide, beclomethasone dipropionate, dexamethasone, hydrocortisone and tixocortol pivalate on cytokine release from leukocytes recovered from human bronchoalveolar lavage fluid Payne A Planquois J M 1997 H-0112 Agonist binding to the Torpedo acetylcholine receptor (II) Complexities revealed by association kinetics. Raftery,MA 1999 H-0112 Mutagenesis of the rat a1 subunit of the ?-aminobutyric acid receptor reveals the importance of residue 101 in determining the allosteric effects of benzodiazepine site ligands. Davies,M Muntoni,AL Lambert,JJ 2000 H-0112 Tyrosine 62 of the ?-aminobutyric acid type A receptor Newell,JG Davies,M Bateson,AN 1997 H-0112 Agonist binding to the Torpedo acetylcholine receptor (I) Complexities revealed by dissociation kinetics. Raftery,MA 1998 H-0112 ATP receptor-mediated enhancement of fast excitatory neurotransmitter release in the brain Khakh,BS 1997 H-0112 ATP-gated cation channels (P2x purinoceptors) in trigeminal mesencephalic nucleus neurones of the rat Khakh,BS Humphrey,PPA 1998 H-0112 Somatostatin receptor desensitization in NG108-15 cells: a consequence of receptor sequestration? Beaumont,VL Hepworth,MB Luty,JS 1998 H-0112 Glycine and GABAA receptor-mediated synaptic transmission in rat substantia gelatinosa: inhibition by Grudt,TJ 1998 H-0112 Pharmacological differentiation of kainate receptors on neonatal rat spinal motoneurones and dorsal roots. Thomas,NK Hawkins,LM Miller,JC 2000 H-0112 Native NMDA receptors containing NR2A and NR2B subunits have pharmacologically-distinct competitive antagonist binding sites. Christie,JM Monaghan,DT 1999 H-0112 Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Schoepp,DD Monn,JA 1999 H-0112 Antagonist activity of a-substituted 4-carboxyphenylglycine analogues at group I metabotropic glutamate receptors expressed in CHO cells. Doherty,AJ Collingridge,GL 1999 H-0112 Selective reduction in A2 adenosine receptor desensitization following antisense-induced suppression of G protein-coupled receptor kinase 2 expression. Willets,JM Parent,J-L Benovic,JL 1997 H-0112 A dominant negative mutant of the G protein-coupled receptor kinase 2 selectively attenuates adenosine A2 receptor desensitization Mundell,SJ Benovic,JL 2000 H-0112 Arrestin isoforms dictate differential kinetics of A2B adenosine receptor trafficking. Mundell,SJ Matharu,A-L Benovic,JL 1998 H-0112 Somatostatin receptor desensitization in NG108-15 cells: a consequence of receptor sequestration? Beaumont,VL Hepworth,MB Luty,JS 1998 H-0112 Functional evidence for a novel suramin-insensitive pyrimidine receptor in rat small pulmonary arteries. Hartley,SA Kato,K 1999 H-0112 Relaxation of endothelin-1 induced pulmonary arterial constriction by niflumic acid and NPPB: mechanism(s) independent of chloride channel block. Kato,K Evans,AM 2000 H-0112 A novel anionic conductance affects action potential duration in isolated rat ventricular myocytes. Spencer,CI Uchida,W 1997 H-0112 Electrophysiological consequences of purinergicreceptor stimulation in isolated rat pulmonary arterial myocytes. Hartley,SA 1998 H-0112 Selective activation of calcium-activated potassium channels by colocalized calcium channels in hippocampal neurons Tavalin,SJ 1997 H-0112 Control of M-current. 1998 H-0112 A novel lipid-anchored A-kinase anchoring protein facilitates cAMP-responsive membrane events Fraser,IDC Tavalin,SJ Lester,LB 1996 H-0112 Calcineurin regulates M-channel modal gating in sympathetic neurons. 1997 H-0112 Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery Cohen,RA Najibi,S Garland,CJ 1999 H-0112 Charybdotoxin and apamin block EDHF in rat mesenteric artery if selectively applied to the endothelium. Doughty,JM Langton,PD 1999 H-0112 Glycoprotein GP Ib-V-IX, a receptor for von Willebrand factor, couples physically and functionally to the Fc receptor g-chain, Fyn and Lyn, to activate human platelets. Falati,S Edmead,CE 1999 H-0112 Thrombin-induced association of SHP-2 with multiple tyrosine-phosphorylated proteins in human platelets. Edmead,CE Crosby,D Southcott,MJG 1997 H-0112 The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen Gibbins,JM Turner,M Van Vugt,MJ 2000 H-0112 Evidence of a role for SHP-1 in platelet activation by the collagen receptor glycoprotein VI. Pasquet,J-M Quek,L Pasquet,S 1997 H-0112 Inhibition of AMPA receptor-stimulated 57Co2+ influx by D- and L-2-amino-4-phosphonobutanoic acid (L-AP4) and L-serine-O-phosphate (L-SOP) in cultured cerebellar granule cells Toms,NJ Hawkins,LM 1996 H-0112 Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures Bruno,V Copani,A Bonanno,L 1999 H-0112 Group I mGlu receptors potentiate synaptosomal [3H]glutamate release independently of exogenously applied arachidonic acid. Reid,ME Toms,NJ Bedingfield,JS 1996 H-0112 The effects of (RS)-a-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist Toms,NJ Jane,DE Kemp,MC 2000 H-0112 Bidirectional modulation of exocytosis by angiotensin II involves multiple G-protein-regulated transduction pathways in chromaffin cells. Teschemacher,AG 2000 H-0112 P2Y purinoceptors inhibit exocytosis in adrenal chromaffin cells via modulation of voltage-operated calcium channels. Powell,AD Teschemacher,AG 1999 H-0112 DIDS, DBDS and suramin cause similar modifications to cardiac ryanodine receptor function. 2000 H-0112 Structural factors that determine the ability of adenosine and related compounds to activate the cardiac ryanodine receptor. Chan,WM Welch,W 1997 H-0112 Development of action potential-dependent and independent spontaneous GABAA receptor-mediated currents in granule cells of postnatal rat cerebellum Wall,MJ 1996 H-0112 Ca2+ entry following store depletion in SH-SY5Y neuroblastoma cells Grudt,TJ Henderson,G 1996 H-0112 Differential inhibition of Ca2+ channels in mature rat cerebellar Purkinje cells by sFTX-3.3 and FTX-3.3 Dupere,JRB Moya,E Blagbrough,IS 1998 H-0112 Development of the quantal properties of evoked and spontaneous synaptic currents at a brain synapse Wall,MJ 1998 H-0112 Insulin dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase. Oatey,PB Tavar Cullen,PJ 1999 H-0112 EGF-and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain. Gunn-Moore,FJ Tavar Cullen,PJ 1998 H-0112 The N-terminal membrane domain of yeast NADPH-cytochrome P450 Oxidoreductase is not required for catalytic activity in sterol biosynthesis or in reconstitution of CYP activity. Lamb,DC Kelly,DE Kelly,SL 2000 H-0112 Signalling via ARF6 lies downstream of PI 3-kinase. Cullen,PJ 1998 H-0112 Development of the quantal properties of evoked and spontaneous synaptic currents at a brain synapse Usowicz,MM 1997 H-0112 Development of action potential-dependent and independent spontaneous GABAA receptor-mediated currents in granule cells of postnatal rat cerebellum Usowicz,MM 2000 H-0114 The P2Y1 receptor closes the N-type Ca2+ channel in neurones, with both adenosine trisphosphates and diphosphates as potent agonists. Filippov, A.K. Brown, D.A. 1998 H-0114 Molecular cloning and characterisation of the rat P2Y4 receptor. Webb, T.E. Henderson, D.J. Roberts, J.A. 1997 H-0114 Xenopus oocytes express a unitary glutamate receptor endogenously. Soloviev, M.M. 1996 H-0114 The P2Y purinoceptor in rat brain microvascular endothelial cells couples to inhibition of adenylate cyclase. Webb, T.E. Feolde, F. Vigne, P. 1999 H-0114 Functional and molecular characterization of a volume-sensitive chloride current in rat brain endothelial cells. Weikersthal von, S.F. Hladky, S.B. 1998 H-0114 Multidrug resistance related transport proteins in isolated human brain microvessels and in cells cultured from these isolates. Seetharaman, S. Maskell, L. Scheper, R.J. 1997 H-0114 Changes in anion permeability following hypotonic challenge in rat brain endothelial cells: a comparison of responses in primary cultures and in immortalised RBE-4 cells. von Weikersthal, S.F. Seetharaman, S. Wright, K.A. 1996 H-0114 Hypotonicity-induced changes in anion permeability of cultured rat brain endothelial cells. von Weikersthal, S.F. Hickman, M.E. Hladky, S.B. 1999 H-0114 Patterned regrowth of n-GaAs by molecular beam epitaxy using arsenic passivation Heinlen, C. Fimland, B-O. Grepstad, J.K. 1999 H-0114 Investigation of protein partnerships using atomic force microscopy. Ellis, D.J. Edwardson, J.M. Henderson, R.M. 1998 H-0114 Preconditioning of c-plane sapphire for GaN molecular beam epitaxy by electron cyclotron resonance plasma nitridation Heinlein, C. Grepstad, J.K. Einfeldt, S. 2000 H-0114 Translocation-independent dimerization of the EcoK1 endonuclease visualized by atomic force microscopy. Ellis, D.J. Dryden, D.T. Edwardson, J.M. 2000 H-0114 Inhibitory effects of glibenclamide on the contraction of human arterial conduits used in coronary artery bypass surgery Crosbie, A.E. Vuylsteke, A. Ritchie, A.J. 1999 H-0114 Changes in reactivity of the digital artery of the fallow deer, Dama dama, in summer and winter. Milton, A.S. Carr, G. Luby, C. 1998 H-0114 Monoamine oxidase activities in human cystic and colonic arteries - influence of age. Figueiredo, I.V. Martinez Coscolla, A. Cotrim, M.D. 1997 H-0114 Amine oxidases in inflammation: fact or fiction? Skamarauskas, J.T. Brown, S. Rainsford, K.D. 1997 H-0114 The secretory granule protein syncollin binds to syntaxin in a Ca2+-sensitive manner. An, S. Jahn, R. 2000 H-0114 Analysis of the association of syncollin with the membrane of the pancreatic zymogen granule. An, S.J. Hansen, N.J. Hodel, A. 1998 H-0114 The relationship between agonist intrinsic activity and the rate of endocytosis of muscarinic receptors in a human neuroblastoma cell line. Szekeres, P.G. Koenig, J.A. 1999 H-0114 Identification of SNAREs involved in regulated exocytosis in the pancreatic acinar cell. Hansen, N.J., Antonin, W. 2000 H-0114 Expression of angiogenic factor thymidine phosphorylase and angiogenesis in human atherosclerosis. Boyle, J.J. Wilson, B. Bicknell, R. 1998 H-0114 Quantification of the repair process involved in the repair of a cell monolayer using an in vitro model of mechanical injury. Lauder, H. Frost, E.E. Hiley, C.R. 1997 H-0114 Sequential development of angiotensin receptors and angiotensin converting enzyme during angiogenesis in the rat subcutaneous sponge granuloma. Walsh, D.A. Hu, D.-E. Wharton, J. 1996 H-0114 Differential effects of angiostatic steroids and dexamethasone on angiogenesis and cytokine levels in rat sponge implants. Hori, Y. Hu, D.-E. Yasui, K. 1998 H-0114 Differential effects of somatostatin and angiopeptin on cell proliferation. Alderton, F. Lauder, H. Fan, T.P.D. 2000 H-0114 Selective somatostatin sst2 receptor blockade with the novel cyclic octapeptide, CYN-154806. Jarvie, E. Luo, J. Humphrey, P.P.A. 1998 H-0114 Differential agonist activity of somatostatin and L-362855 at human recombinant sst4 receptors. Smalley, K.S.M. Humphrey, P.P.A. 1997 H-0114 Characterization of human recombinant somatostatin sst5 receptors mediating activation of phosphoinositide metabolism. Wilkinson, G.F. Humphrey, P.P.A. 1997 H-0114 ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes - a possible sensory mechanism? Kennedy, I. Burton, T.J. 2000 H-0114 Cell cycle delay and apoptosis are induced by high salt and urea in renal medullary cells. Michea, L. Peters, E.M. Andrews, P.M. 1999 H-0114 Urothelial function. 2000 H-0114 Activation of epithelial Na+ channel activity in the rabbit urinary bladder by cAMP. Burton, T.J. Elneil, S. Nelson, C.P. 2000 H-0114 Influence of b-adrenoceptor tone on the cardioprotective efficacy of adenosine A1 receptor acativation in isolated working rat hearts. Jugdutt, B.I. Lopaschuk, G.D. Schulz, R. 2000 H-0125 The role of positively charged amino acids in ATP recognition by human P2X1 receptors Ennion S. Hagan S. 1998 H-0114 K(ATP)-channel activation: Effects on myocardial recovery from ischaemia and role in the cardioprotective response to adenosine A1-receptor stimulation. Lopaschuk, G.D. Schulz, R. Clanachan, A.S. 1996 H-0114 Opposite effects of angiotensin AT1 and AT2 receptor antagonists on recovery of mechanical function after ischemia-reperfusion in isolated working rat hearts. Clanachan, A.S. Jugdutt, B.I. 1998 H-0114 Intrinsic ANG II type 1 receptor stimulation contributes to recovery of postischemic mechanical function. Clanachan, A.S. Lopaschuk, G.D. Schulz, R. 1996 H-0114 Nicotinic acid-adenine dinucleotide phosphate mobilizes Ca2+ from a thapsigargin-insensitive pool Galione, A 1996 H-0114 Unique inactivation properties of NAADP-sensitive Ca2+ release Empson, R.M. Galione, A. 1997 H-0114 Kinetic properties of Nicotinic Acid Adenine Dinucleotide Phosphate--induced Ca2+release. Mezna, M. Summerhill, R.J. Galione, A. 1999 H-0114 Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons Carafoli, E. Guerini, D. 1997 H-0114 The mago nashi gene is required for the polarisation of the oocyte and the formation of perpendicular axes in Drosophila. Micklem, D.R. Dasgupta, R. Elliott, H. 2000 H-0114 The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. Karlsson, C. Still, I. Cowell, J. 2000 H-0114 D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo. Kidd, D. Jeffers, K. Wakefield, J.A. 1996 H-0114 Imaging ROMK1 inwardly rectifying ATP-sensitive K+ channel protein using atomic force microscopy. Schneider, S. Li, Q. Hornby, D. 1997 H-0114 Structural activity of a cloned potassium channel (ROMK1) monitored with the atomic force microscope: the molecular-sandwich technique. Oberleithner, H. Schneider, S.W. 2000 H-0114 A cell-free system for regulated exocytosis on PC12 cells. Avery, J. Ellis, D.J. Lang, T. 1999 H-0114 Direct observation of DNA translocation and cleavage by the EcoKI endonuclease using atomic force microscopy. Ellis, D.J. Dryden, D.T. Berge, T. 1997 H-0125 ATP-sensitive and inwardly rectifying potassium channels in smooth muscle Quayle, J.M. Nelson, M.T. 2000 H-0114 Hyperpolarisation of rat mesenteric endothelial cells by ATP-sensitive K+ channel openers. White, R. 1998 H-0114 The actions of some cannabinoid receptor ligands in the rat isolated mesenteric artery. White, R. 1997 H-0114 A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery. White, R. 1997 H-0114 Endothelium and cannabinoid receptor involvement in levcromakalim vasorelaxation. White, R. 2000 H-0114 Thrombin stimulation of platelets causes an increase in phosphatidylinositol 5-phosphate revealed by mass assay. Morris, J.B. Ciruela, A. Letcher, A. 1998 H-0114 PIPkins, their substrates and their products; new functions for old enzymes. Ciruela, A. Irvine, R.F. 1998 H-0114 Regulation of PtdIns 4-P 5-kinase C by thrombin-stimulated changes in its phosphorylation state in human platelets. Irvine, R.F. Divecha, N. 1999 H-0114 Regulation of type IIa phosphatidylinositol phosphate kinase localisation by the protein kinase CK2. Ciruela, A. Letcher, A. Divecha, N. 1996 H-0114 Hypotonicity-induced anion fluxes in cells expressing the multidrug resistance associated protein, MRP. Hainsworth, A.H. Henderson, R.M. Hickman, M.E. 1998 H-0114 Streaming potentials in gramicidin channels measured with ion selective microelectrodes. Tripathi, S. 2000 H-0114 Adjustments for the display of quantized ion channel dwell times in histograms with logarithmic bins. Stark, J.A. 2000 H-0114 Use of membrane vesicles to investigate drug interactions with transporter proteins, P-glycoprotein and multidrug resistance-associated protein. Wheeler, R. Neo, S.-Y. Chew, J. 1997 H-0114 Somatostatin5 receptor-mediated [35S]Guanosine-5'-0-(3-thio)triphosphate binding: agonist potencies and the influence of sodium chloride on intrinsic activity. Williams, A .J. Michel, A.D. Feniuk, W. 1998 H-0114 Blockade of human P2X7 receptor function with a monoclonal antibody. Buell, G. Chessell, I.P. Michel, A.D. 1997 H-0114 Acute nociception mediated by hindpaw P2X receptor activation in the rat. Bland-Ward, P.A. 1999 H-0114 Activation of adenylate cyclase by human recombinant sst5 receptors expressed in CHO-K1 cells and involvement of Gas proteins. Carruthers, A.M. Warner, A.J. Michel, A.D. 2000 H-0114 Nuclear targeting of the B isoform of Type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its a-helix 7. Ciruela, A. Hinchcliffe, K. A. Divecha, N 1999 H-0114 PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase. Schell, M.J. Letcher, A.J. Brearley, C.A. 1996 H-0114 Aggregation-dependent, integrin-mediated increases in cytoskeletally associated PtdInsP2(4,5) levels in human platelets are controlled by translocation of PtdIns 4-P 5-kinase C to the cytoskeleton. Hinchliffe, K.A., Divecha, N. 1999 H-0114 Nuclei contain two differentially regulated pools of diacylglycerol. D'Santos, C. Clarke, J.H. Divecha, N. 1998 H-0114 Fates of endocytosed somatostatin sst2 receptors and associated agonists. Kaur, R. Edwardson, J.M. Dodgeon, I. 1997 H-0114 Somatostatin receptors in Neuro2A neuroblastoma cells: operational characteristics. Edwardson, J.M. Humphrey, P.P.A. 1997 H-0114 Somatostatin receptors in Neuro2A neuroblastoma cells: ligand internalization. Edwardson, J.M. Humphrey, P.P.A. 1998 H-0114 Involvement of receptor cycling and receptor reserve in resensitization of muscarinic responses in SH-SY5Y human neuroblastoma cells. Szekeres, P.G. Edwardson, J.M. 1996 H-0114 Cytotoxic, nuclear, and growth inhibitory effects of photodynamic drugs on pancreatic carcinoma cells. Ward, A.J. 2000 H-0114 Photosensitizon of pancreatic tumour cells by d -aminolaevulinic acid esters. Whitaker, C.J. Battah, S.H. Forsyth, M.J. 1996 H-0114 Dynamics of actin measured by fluorescence correlation microscopy (FCM). Terry, B.R. 2000 H-0114 A key role for the mitochondrial benzodiazepine receptor in cellular photosensitisation with d-aminolaevulinic acid. Mesenholler, M. 1999 H-0114 Specific involvement of PKC-e in sensitization of the neuronal response to painful heat. Cesare, P. Dekker, L.V. Sardini, A. 2000 H-0114 Modulation of the synaptic Ca2+ current in salamander photoreceptors by polyunsaturated fatty acids and retinoids. Vellani, V. Reynolds, M.R. 1997 H-0114 Actions of serum and plasma albumin on [Ca2+]i in human endothelial cells. Fuentes, E. Nadal, A. Jacob, R. 1996 H-0114 A novel heat-activated current in nociceptive neurones and its sensitization by bradykinin. Cesare, P. 1998 H-0114 Cibacron blue allosterically modulates the rat P2X4 receptor. Miller, K.J. Chessell, I.P. Humphrey, P.P.A. 1997 H-0114 Radiolabeling of the rat P2X4 purinoceptor: evidence for allosteric interactions of purinoceptor antagonists and monovalent cations with P2X purinoceptors. Miller, K.J. Lundstrom, K. Buell, G.N. 2000 H-0114 Apparent species differences in the kinetic properties of P2X7 receptors. Hibell, A.D. Kidd, E.J. Chessell, I.P. 1999 H-0114 Ionic effects on human recombinant P2X7 receptor function. Chessell, I.P. Humphrey, P.P.A. 1998 H-0114 Dopamine modulates the susceptibiity of striatal neurons to 3-nitropropionic acid in the rat model of Huntington's disease. Reynolds, D.S. Carter, R.J. 1999 H-0114 Characterisation of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. Carter, R.J. Lione, L.A. Humby, T. 2000 H-0114 Mice transgenic for the Huntington's Disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity Hickey, M.A. 2000 H-0114 Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's Disease mutation Murphy, K.P.S.J. Carter, R.J. Lione. L.A. 1999 H-0114 Molecular mechanism for sodium-dependent activation of G protein-gated K+ channels Ho, I.H.M. 1997 H-0114 Molecular determinants for assembly of G-protein-activated inwardly rectifying K+ channels. Woodward, R. Stevens, E.B. 1999 H-0114 Molecular determinants for sodium-dependent activation of G protein-gated K+ channels. Ho, I.H.M. 1999 H-0114 Identification of amino acids within the P2X2 receptor C-terminus that regulate desensitization. Smith, F.M. Humphrey, P.P.A. 1999 H-0125 Characterization of cultured dorsal root ganglion neuron P2X receptors Evans R.J 2000 H-0114 Adenosine receptor expression and function in rat striatal cholinergic interneurones. Preston, Z. Lee, K Freeman, T.C. 1998 H-0114 Identification of an ATP sensitive potassium channel current in rat striatal cholinergic interneurones. Lee, K. Dixon, A Freeman, T.C. 1998 H-0114 Expression profiling of single cells using three prime end amplification (TPEA) PCR. Dixon, A. Lee, K. Carter, N.P. 2000 H-0114 Correlating cell physiology with gene expression in single neurons Dixon, A. Lee, K. Bell, M.I. 2000 H-0114 Receptor isoforms mediate opposing proliferative effects through Gbg-activated p38 or Akt pathways. Alderton, F. Carruthers, A.M. Schindler, M. 1999 H-0114 Prolonged activation of extracellular signal-regulated kinase by a protein kinase C-dependent and N17Ras-insensitive mechanism mediates the proliferative response of Gi/o-coupled somatostatin sst4 receptors. 1997 H-0114 Somatostatin sst5 inhibition of receptor mediated regeneration of rat aortic vascular smooth muscle cells. Lauder, H. Fan, T.-P.D. Feniuk, W. 1999 H-0114 Activated G protein-coupled receptor induces tyrosine phosphorylation of STAT3 and agonist-selective serine phosphorylation via sustained stimulation of mitogen-activated protein kinase. Feniuk, W. Humphrey, P.P.A. Lauder, H. 1997 H-0114 Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic b-cells Sakura, H. Coles, B. Gummerson, N. 1999 H-0114 Direct effects of tolbutamide on mitochondrial function, intracellular Ca2+ and exocytosis in pancreatic b-cells. Proks, P. Moorhouse, A. 1999 H-0114 Quantal analysis of 5-hydroxytryptamine release from mouse pancreatic b-cells. Proks, P. Ashcroft, F.M. 1998 H-0114 Inhibition of the ATP-sensitive potassium channel from mouse pancreatic b-cells by surfactants. Proks, P. 2000 H-0114 Parathyroid hormone controls the size of the intracellular Ca2+ stores available to receptors linked to inositol trisphosphate formation. Short, A.D. 1999 H-0114 Lateral inhibition of inositol 1,4,5-trisphosphate receptors by cytosolic Ca2+. Adkins, C.E. 1997 H-0114 Cooperative activation of IP3 receptors by sequential binding of IP3 and Ca2+ safeguards against spontaneous activity. Marchant, J.S. 1997 H-0114 Ca2+-independent inhibition of inositol trisphosphate receptors by calmodulin: Redistribution of calmodulin as a possible means of regulating Ca2+ mobilization. Patel, S. Morris, S.A. Adkins, C.E. 2000 H-0114 Real-time studies of zymogen granule exocytosis in intact rat pancreatic acinar cells. Campos-Toimil, M. Edwardson, J.M. 1996 H-0114 The LbT2 clonal gonadotrope: a model for single cell studies of endocrine cell secretion. Mellon, P.L. Turgeon, J.L. Waring, D.W. 2000 H-0114 Tetrabutylammonium: a selective blocker of the somatostatin-activated hyperpolarizing current in mouse AtT-20 corticotrophs. Smith, P. 1997 H-0114 Modulation of stimulus-secretion coupling in single rat gonadotrophs. Waring, D.W. 2000 H-0125 A structural basis for drug-induced long QT syndrome Chen J. Lin M. Culberson C. 1999 H-0114 The role of Ca2+ feedback in shaping InsP3-evoked Ca2+ signals in mouse pancreatic acinar cells. Kidd, J.F. Fogarty, K.E. Tuft, R.A. 2000 H-0114 A bimodal pattern of InsP3-evoked elementary Ca2+ signals in pancreatic acinar cells. Fogarty, K.E. Kidd, J.F. Tuft, R.A. 2000 H-0114 Microtubules regulate local Ca2+ spiking in secretory epithelial cells. Fogarty, K. E. Kidd, J. F. Turner, A. 1996 H-0114 Multiple, coordinated Ca2+-release events underlie the inositol trisphosphate-induced local Ca2+ spikes in mouse pancreatic acinar cells. Moreton, R. Berridge, M. 1996 H-0114 Multidrug resistance in Lactococcus lactis: evidence for ATP-dependent drug extrusion from the inner leaflet of the cytoplasmic membrane. Bolhuis, H. Molenaar, D. Poolman, B. 2000 H-0114 The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism. Margolles, A. Muller, M. Higgins, C.F. 1996 H-0114 Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1. Venema, K. Bolhuis, B. Oussenko, I. 1998 H-0114 A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene. Callaghan, R. Soceneantu, L. Sardini, A. 2000 H-0114 Quinaxaline antibiotics enhance peptide nucleic acid binding to double-stranded DNA. Mollegaard, N.E. Bailly, C. Nielsen, P.E. 1999 H-0114 Reactivity of guanine at m5CpG steps in DNA: evidence for electronic effects transmitted through the base pairs. Das, A. Tang, K.S. Gopalakrishnan, S. 1999 H-0114 Demethylation of thymine residues affects DNA cleavage by endonucleases but not sequence recognition by drugs. Bailly, C. Crow, S. Minnock, A. 1998 H-0114 The exocyclic groups of DNA modulate the affinity and positioning of the histone octamer. Buttinelli, M. Minnock, A. Panetta, G. 1998 H-0114 The actions of the cannabinoid receptor antagonist, SR141716A, in the rat isolated mesenteric artery. Hiley, C.R. 2000 H-0114 Human urotensin-II is an endothelium-dependent vasodilator in rat small arteries. Bottrill, F.E. Douglas, S.A. Hiley, C.R. 1998 H-0114 Effects of K+ channel openers on relaxations to nitric oxide and endothelium-derived hyperpolarizing factor in rat mesenteric artery. Hiley, C.R. 2000 H-0114 Interaction of cyclic AMP modulating agents with levcromakalim in the relaxation of rat isolated mesenteric artery. Omar, R. Bottrill, F.E. Hiley, C.R. 1998 H-0114 Dual effects of histamine and substance P on intracellular calcium levels in human U373 MG astrocytoma cells: role of protein kinase C. Young, K.W. Pinnock, R.D. Gibson, W.J. 2000 H-0114 Characateristics of the Ca2+-dependent inhibition of cyclic AMP accumulation by histamine and thapsigargin inhuman U373 MG astrocytoma cells. Wong, M.-P.W. Cooper, D.M.F. Young, K.W. 1997 H-0114 Histamine H3 receptor activation selectively inhibits dopamine D1 receptor-dependent [3H]-g-aminobutyric acid release from depolarisation-stimulated slices of rat substantia nigra pars reticulata. Garcia, M. Floran, B. Arias-Montano, J.A. 1998 H-0114 Ca2+/calmodulin-mediated regulation of agonist-induced sequestration of Gq protein-coupled histamine H1-receptors in human U373 MG astrocytoma cells. Hishinuma, S. Naiki, A. Tsuga, H. 1999 H-0125 MEK kinase 3 directly activates MKK6 and MKK7, specific activators of the p38 and c-Jun NH2-terminal kinases Deacon, K. 1996 H-0125 Presynaptic calcium current modulation by a metabotropic glutamate receptor Takahashi, T. Tsujimoto T. Barnes-Davies M 1999 H-0125 Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G protein-linked muscarine acetylcholine receptors Wylie P.G. Challiss, R.A.J. 1996 H-0125 Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase Gerwins, P. Elliott, E.M. Sather, S. 1997 H-0125 Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase1 and MKK3/p38 pathways regulated by MEK Kinase 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo Deacon, K. 1999 H-0125 Lysophosphatidic acid-induced calcium mobilization and proliferation in kidney proximal tubular cells Dixon R.J. Young K.W. 1999 H-0125 Lysophosphatidic acid-induced proliferation in opossum kidney proximal tubular cells: Role of PI 3-kinase and ERK Dixon R.J. 1998 H-0125 Receptor-mediated endocytosis of albumin by kidney proximal tubule cells is regulated by phosphatidylinositide 3-kinase Stuart J. Tobin A.B. Walls J. 1999 H-0125 Activation of mitogenic pathways by albumin in kidney proximal tubule epithelial cells: Implications for the pathophysiology of proteinuric states Dixon R.J. 1996 H-0125 Binding of 2'(3')-O-(2,4,6- trinitrophenyl)ADP to soluble alphabeta protomers of Na,K-ATPase modified with fluorescein isothiocyanate - Evidence for two distinct nucleotide sites Ward D.G. 1998 H-0125 Photoinactivation of fluorescein isothiocyanate-modified Na,K-ATPase by 2'(3')-0-(2,4,6-trinitrophenyl)8-azidoadenosine 5'-diphosphate. Abolition of E1 and E2 partial reactions by sequential block of high and low-affinity nucleotide sites Ward, D.G. 1998 H-0125 Affinity labeling of two nucleotide sites on Na,K-ATPase using 2 Ward D.G. 1997 H-0125 K+ induces an acid-labile phosphoenzyme (or an occluded Pi form) in Na,K-ATPase Buxbaum, E. Ward, D.G. Walton, T. J. H. 1998 H-0125 Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells Willars, G.B Nahorski, S.R. 1996 H-0125 Stable overexpression of the type-1 inositol 1,4,5-trisphosphate receptor in L fibroblasts: subcellular distribution and functional consequences Mackrill J.J. Wilcox R.A. Miyawaki A., 1999 H-0125 Inhibition of N-linked glycosylation of the human type 1alpha metabotropic glutamate receptor by tunicamycin: effects on cell-surface expression and function Mody N. Hermans E. Nahorski S.R. 2000 H-0125 Complex involvement of pertussis toxin-sensitive G-proteins in the regulation of type 1alpha metabotropic glutamate receptor signalling in BHK cells Hermans E. Saunders R. Selkirk J.V. 1999 H-0125 Direct block of native and cloned (Kir2.1) inward rectifier K+ channels by chloroethylclonidine Barrett-Jolley, R. Standen N.B. 1998 H-0125 The dependence of Ag+-block of a potassium channel, murine Kir2.1, on a cysteine residue in the selectivity filter Leyland, M.L. Barrett-Jolley, R.A. Shelton P.A. 1998 H-0125 The selectivity filter of a potassium channel, murine Kir2.1, investigated using scanning cysteine mutagenesis Leyland, M.L. Spencer P.J. Stanfield P.R. 1996 H-0125 The properties and distribution of inward rectifier potassium currents in pig coronary arterial smooth muscle Quayle, J.M. Standen N.B. 2000 H-0125 A residue in the intracellular vestibule of the pore is critical for gating and permeation in Ca2+-activated K+ (BKca) channels Lippiat, J.D. Standen N.B. 1998 H-0125 Block of cloned BKCa channels (rSlo) expressed in HEK 293 cells by N-methyl D-glucamine Lippiat, J.D. Standen N.B. 1997 H-0125 Kinetic analysis of the inhibitory effect of glibenclamide on KATP channels of mammalian skeletal muscle Barrett-Jolley, R. 1996 H-0125 A rate theory model for Mg2+ block of ATP-dependent potassium channels of rat skeletal muscle McKillen, H.-C. Stanfield, P.R. Standen, N.B. 2000 H-0125 P2 receptor mediated control of rat cerebral (pial) microvasculature; contribution of P2X and P2Y receptors Lewis C.J. Ennion S. 1998 H-0125 2',3'-0-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels Lewis C.J. Surprenant A. 2000 H-0125 Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors Mulryan K. Gitterman D.P. Lewis C.J. 1998 H-0125 Contrasting Ca2+ channel subtypes at cell bodies and synaptic terminals of rat anterioventral cochlear bushy neurones Doughty, J.M. Barnes-Davies M., Rusznak Z., 2000 H-0125 Characterisation of inhibitory and excitatory postsynaptic currents of the rat medial superior olive Smith A.J. Owens S. 1998 H-0125 Inactivation of presynaptic calcium current contributes to synaptic depression at a fast central synapse Tsujimoto T. Barnes-Davies M. Cuttle M.F. 2000 H-0125 Cyclooxygenase-1 is a marker for a sub-population of putative nociceptive neurones in rat dorsal root ganglia Chopra B. Giblett S. Little J.G. 1997 H-0125 Prostanoids synthesised by cyclooxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability Willingale, H.L. Gardiner, N.J. McLymont, N. 1999 H-0125 The intraspinal release of prostaglandin E2 in a model of acute arthritis is accompanied by an upregulation of cyclooxygenase-2 in the spinal cord Ebersberger A. Willingale H.L. Gardiner N.J. 1999 H-0125 An investigation of the role played by the E-4031-sensitive (rapid delayed rectifier) potassium current in isolated rabbit atrioventricular nodal and ventricular myocytes Hancox J.C. 2000 H-0125 Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel Chen J. Lin M. Sanguinetti M.C. 2000 H-0125 Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate Chen J. Sanguinetti M.C. 2000 H-0125 Lysophosphatidic acid-induced Ca2+ mobilisation requires intracellular sphingosine 1-phosphate production: potential involvement of endogenous Edg-4 receptors Young K.W. Bootman M.D. Channing D.R. 1999 H-0125 Enhanced purinoceptor-mediated Ca2+ signalling in L-fibroblasts overexpressing type 1 inositol 1,4,5-trisphosphate receptors Davis R.J. Challiss R.A.J. 1997 H-0125 Enhanced type 1alpha metabotropic glutamate receptor-stimulated phosphoinositide signalling after pertussis toxin treatment Carruthers A.M. Challiss R.A.J. Mistry R. 1996 H-0125 Identification of a novel receptor kinase that phosphorylates a phospholipase C-linked muscarinic receptor Tobin A.B. Keys B. 1999 H-0125 ATP controls neuronal apoptosis triggered by microtubule breakdown or potassium deprivation Volbracht, C. Leist M. 1998 H-0125 1-methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation and neuronal apoptosis Leist, M. Volbracht, C. Fava, E. 1997 H-0125 The novel SAR-binding domain of scaffold attachment factor A (SAF-A) is a target in apoptotic nuclear breakdown Gohring, F. Schwab, B.L. Leist, M. 1999 H-0125 Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity Hansson, O Petersen, A Leist, M 2000 H-0125 Bidirectional modulation of exocytosis by angiotensin II involves multiple G-protein-regulated transduction pathways in chromaffin cells Treschemacher A.G. 2000 H-0125 P2Y purinoceptors inhibit exocytosis in adrenal chromaffin cells via modulation of voltage-operated calcium channels Powell A.D. Treschmacher A.G. 1997 H-0125 Angiotensin II inhibition of ATP-sensitive K+ currents in rat arterial smooth muscle cells through protein kinase C Kubo, M. Quayle, J.M. 2000 H-0125 Mechanisms that regulate [Ca2+]i following depolarisation in rat systemic arterial smooth muscle cells Kamishima, T. Davies, N.W. 1998 H-0125 ATP-sensitive K+ channel activation by calcitonin gene-related peptide and protein kinase A in pig coronary arterial smooth muscle Wellman, G.C. Quayle, J.M. 1999 H-0125 The possible role of disulphiode bond in forming functional Kir2.1 potassium channels Leyland, M.L. Dart C. Spencer P.J. 1997 H-0125 Membrane currents influencing action potential latency in granule neurons of the rat cochlear nucleus Rusznak Z. Forsythe I.D. Brew H.M. 1999 H-0125 Activation of the mitogen-activated protein kinase pathway by a Gq/11 coupled muscarinic receptor is independent of receptor internalisation Budd D.C. Rae A. 1999 H-0125 Cross-talk between m3-muscarinic and beta2-adrenergic receptors at the level of receptor phosphorylation and desensitisation Budd D.C. Challiss R.A.J. Young K.W. 1997 H-0125 Stimulus-Dependent Phosphorylation of G-Protein Coupled Receptors By Casein Kinase 1alpha Totty N.F. Sterlin A.E. Nahorski S.R. 2000 H-0125 Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha Budd D.C. McDonald J.E. 1998 H-0125 Acute desensitization of phospholipase C-coupled muscarinic M3 receptors but not gonadotropin-releasing hormone receptors co-expressed in alphaT3-1 cells: implications for mechanisms of rapid desensitization McArdle, C.A. Nahorski, S.R. 1999 H-0125 Pivotal role for the cytoplasmic carboxyl-terminal tail of a nonmammalian gonadotropin-releasing hormone receptor in cell surface expression, ligand binding, and receptor phosphorylation and internalization Blomenroehr, M. Heding A. Sellar, R. 1999 H-0125 Receptor phosphorylation does not mediate cross-talk between muscarinic M3- and bradykinin B2 receptors. Mueller-Esterl, W. Nahorski, S.R. 1999 H-0125 Lack of a C-terminal tail in the mammalian gonadotropin -releasing hormone receptor confers resistance to agonist-dependent phosphorylation and rapid desensitization Heding A. Vrecl M. Sellar R. 1998 H-0126 Effect of ribavirin on zidovudine efficacy and toxicity in vitro: A concentration dependent interaction Sim SM Hoggard PG Sales SM 1999 H-0126 Modulation of P-glycoprotein function in human lymphocytes and Caco-2 cell monolayers by HIV-1 protease inhibitors. Profit L Eagling VA 1999 H-0126 The pharmacokinetics of lamivudine phosphorylation in peripheral blood mononuclear cells from patients infected with HIV-1. Moore KHP Barrett JE Shaw S 1999 H-0126 Interaction of sildenafil and indinavir when co-administered to HIV-positive patients Merry C Barry MG Ryan M 1998 H-0126 Pharmacokinetics of combination therapy with nelfinavir plus nevirapine. Merry C Barry MG Mulcahy F 1999 H-0126 Quattro Steering Committee (A. Breckenridge, Chairman). A randomised trial comparing regimens of four reverse transcriptase inhibitors given together or cyclically in HIV-1 Infection Babiker A Back DJ Blatchford N 1997 H-0126 Saquinavir kinetics alone and in combination with ritonavir in HIV infected patients Merry C Barry MG Mulcahy F 1996 H-0126 Delta Steering Committee (A. Breckenridge, Chairman). Delta Aber V Aboulker J-P Babiker AG 2000 H-0126 Effects of mefloquine on cardiac contractility and electrical activity in vivo, in isolated cardiac preparations, and in single ventricular myocytes Batey AJ Lightbown ID Diaz ME 1997 H-0126 Comparison of the acute cardiotoxicity of the antimalarial drug halofantrine in vitro and in vivo in anaesthetized guinea pigs Batey AJ Lightbown ID Lambert JP 1999 H-0126 Potential interactions between iloprost and SIN-1 on platelet aggregation and myocardial infarct size Aitchison KA 1997 H-0126 Tumour necrosis factor-a expression and cell recruitment in Sephadex particle-induced lung inflammation: effects of dexamethasone and cyclosporin A Williams CMM Smith L Flanagan BF 1999 H-0126 Reciprocal effects of interleukin-4 and interferon-g on immuno-globulin E-mediated mast cell degranulation: a role for nitric oxide but not peroxynitrite or cyclic guanosine monophosphate DeSchoolmeester ML Eastmond NC Dearman RJ 2000 H-0126 Presentation of IFN-g to nitric oxide oxide-producing cells : a novel function for mast cells Brooks B Briggs DM Eastmond NC 1997 H-0126 Nitric oxide inhibits IgE-mediated degranulation of mast cellsand is the principal intermediate in IFN-g-induced suppression of exocytosis Eastmond NC Banks EMS 1998 H-0126 Synthesis and antimalarial activity of sixteen dispiro-1,2,4,5-tetroxane analogs of WR 148999 Vennerstrom J Dong Y Andersen SL 1998 H-0126 Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes Batty KT Ilett KF Powell SM 1997 H-0126 The biliary metabolites of b-artemether, an endoperoxide antimalarial Maggs JL Bishop LPD O'Neill PM 1999 H-0126 Enhanced in vitro neurotoxicity of artemisinin derivatives in the presence of haem Smith SL Fishwick J McLean WG 1999 H-0126 Clinical guidelines Bagust A Walley T 1998 H-0126 Cost-effectiveness of treatment for GORD in clinical practice Eggleston A Wigerinck A Huijghebgert S 1999 H-0126 The North Staffordshire Community beds study Unsworth L Allen K Hodgson R 1998 H-0126 An integrated national pharmaceutical policy for the United Kingdom? Walley T Earl-Slater A Bagust A 1997 H-0126 The integrin-triggered rescue of T lymphocyte apoptosis is blocked in HIV-1 infected individuals Ng TTC Kanner SB Humphries MJ 1999 H-0126 Adenoviruses from human immunodeficiency virus-infected individuals, including two strains that represent new candidate serotypes Ad50 and Ad51 of subspecies B1 and D respectively De Jong JC Hierholzer JC van Doornum GJJ 1998 H-0126 Influenza-like episodes in HIV-positive patients: the role of viral and atypical infections Hajia M Klapper PE Wilkins EGL 1997 H-0126 Tumour Necrosis Factor c2 microsatellite allele is associated with the rate of HIV disease progression Ollier WER Hajeer A Snowden N 1996 H-0126 Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: studies with cis-stilbene oxide, carbamazepine 10, 11-epoxide and naphthalene Davis C Howard N Pirmohamed M 1999 H-0126 Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity Hough SJ Gill HJ Pirmohamed M 1997 H-0126 The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat Gill HJ Hough SJ Naisbitt DJ 1998 H-0126 Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype Powell H Pirmohamed M Smith DA 1997 H-0126 Disposition of amodiaquine and related antimalarials in human neutrophils: Implications for drug design. Ruscoe JE Williams DP O'Neill PM 1998 H-0126 Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs Williams DP Maggs JL Pirmohamed M 2000 H-0126 Plasma cysteine deficiency and decreased reduction of nitrosulfamethoxazole with HIV infection Vilar FJ Stalford AC Wilkins EGL 2000 H-0126 Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals. Schnyder B Burkhart C Schnyder-Frutig K 2000 H-0126 Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of a-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen-DNA adducts Boocock DJ Maggs JL Brown K 1999 H-0126 Novel, potent, semisynthetic antimalarial carba analogues of the first-generation 1,2,4-trioxane artemether O'Neill PM Searle NL Kan KW 2000 H-0126 Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi Henderson CJ Wolf CR Kitteringham N 2000 H-0126 Hepatocellular response to chemical stress in CD-1 mice: Induction of early genes and g-glutamylcysteine synthetase Kitteringham NR Powell H Clement YN 1996 H-0126 Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency Williams DP Wilkins EGL Park BK 1999 H-0126 Induction of metabolism-dependent and Naisbitt DJ Williams DP Park BK 2000 H-0126 Association analysis of drug metabolising enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole Alfirevic A Vilar J Stalford A 1999 H-0126 The effect of the CYP2C9 genetic polymorphisms on sulphamethoxazole N-hydroxylation Gill HJ Kitteringham NR Park BK 2000 H-0126 Interpretation of data protection legislation - barriers to research Strobl J Pickworth E 1996 H-0126 Influences of practice characteristics on prescribing in fundholding and non-fundholding general practices Wilson R Hatcher J Barton S 2000 H-0126 Lifestyle Medicines Gilbert D New B 1999 H-0126 The General Practice Research Database Mantgani A 1996 H-0126 4-Aminoquinoline resistance of Plasmodium falciparum: insights from the study of amodiaquine uptake Bray PG Hawley SR 1998 H-0126 Access to heamatin: the basis of chloroquine resistance Bray PG Mungthin M Ridley RG 1999 H-0126 Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum Bray PG Janneh O Raynes KJ 1996 H-0126 Physicochemical properties correlated with drug resistance and its reversal in Plasmodium falciparum Bray PG Hawley SR 1997 H-0126 Chlorproguanil-dapsone: an effective treatment for uncomplicated falciparum malaria. Watkins W Hatcher J Lowe B 2000 H-0126 Effect of phenobarbital on seizure frequency and mortality in childhhood cerebral malaria Crawley J Waruiru C Mithwani S 2000 H-0126 Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum Nzila AM Nduati E Watkins WM 2000 H-0126 Towards an understanding of the mechanism of pyrimethamine- sulfadoxine resistance in Plasmodium falciparum: the genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites. N'zila A Sibley C Mberu E 1999 H-0139 B1 receptors as a new inflammatory target. Could this B the 1?. Perretti 1999 H-0139 Cholinergic Contraction is Altered in nNOS Knockouts: Co-operative Modulation of Neural Bronchoconstriction by nNOS and COX Kakuyama M Rodrigo J Vallance P 2000 H-0139 Evaluation of the postprandial effects of a fast-food meal on human plasma F(2)-isoprostane levels. Gopaul NK Zacharowski K Halliwell B 1996 H-0139 Investigation of endogenous nitric oxide vascular function in the carotid artery of cholesterol-fed rabbits. Laight D Matz J Caesar B 1999 H-0139 F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease. Nourooz-Zadeh Liu EH Yhlen B 1999 H-0139 Photoplethysmographic assessment of pulse wave reflection: blunted response to endothelium-dependent beta2-adrenergic vasodilation in type II diabetes mellitus. Chowienczyk PJ Kelly RP MacCallum H 2000 H-0139 Engineering mouse T lymphocytes specific to type II collagen by transduction with a chimeric receptor consisting of a single chain Fv and TCR zeta [In Process Citation] Chernajovsky Y 2000 H-0139 Soluble complement receptor 1 (CD35) delivered by retrovirally infected syngeneic cells or by naked DNA injection prevents the progression of collagen-induced arthritis. Dreja H Chernajovsky Y 1996 H-0139 The beta 2 integrin Mac-1 but not p150,95 associates with Fc gamma RIIA. Ortlepp S Hogg N 1998 H-0139 Loss of original antigenic specificity in T cell hybridomas transduced with a chimeric receptor containing single-chain Fv of an anti-collagen antibody and Fc epsilonRI-signaling gamma subunit. Moyes SP Eshhar Z Mageed RA 1999 H-0139 Getting to the heart of the matter. Pyne D Rothman MT 1999 H-0139 Platelet IIb/IIIa antagonists followed by delayed stent implantation. A new treatment for vein graft lesions containing massive thrombus. Robinson N Dymond D 1999 H-0139 How should age affect management of acute myocardial infarction? A prospective cohort study [see comments] Wilkinson P Deaner A Fluck D 2000 H-0139 Acute myocardial infarction in women: contribution of treatment variables to adverse outcome [In Process Citation] Wilkinson P Suliman A Ranjadayalan 1999 H-0139 Effect of nitric-oxide-generating system on microcirculatory blood flow in skin of patients with severe Raynaud's syndrome: a randomised trial. Tucker AT Pearson RM Cooke ED 1996 H-0139 Plasma nitrate concentration in infective gastroenteritis and inflammatory bowel disease. Dykhuizen RS Masson J McKnight G 1998 H-0139 Helicobacter pylori is killed by nitrite under acidic conditions. Dykhuizen A Fraser A McKenzie 1996 H-0139 Antimicrobial effect of acidified nitrite on gut pathogens: importance of dietary nitrate in host defense. Dykhuizen PS Frazer R Duncan C 1997 H-0139 Induction of cyclooxygenase-2 in human saphenous vein and internal mammary artery. Pepper JR Haddad EB Newton R 2000 H-0139 Bisphenol A diglycidyl ether (BADGE) is a PPARgamma agonist in an ECV304 cell line. Hla T Warner TD 1999 H-0139 Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2. Hla T 1998 H-0139 Differential induction of cyclooxygenase-2 in human arterial and venous smooth muscle: role of endogenous prostanoids. Pepper JR Larkin SW Mitchell JA 1996 H-0139 Increase by adrenaline or angiotensin II of the accumulation of low density lipoprotein and fibrinogen by aortic walls in unrestrained conscious rats. Cardona-Sanclemente LE 2000 H-0139 Effects of reserpine on expression of LDL receptor in liver and on plasma and tissue lipids, low density lipoprotein and fibrinogen in rabbits in vivo. Shafi S Stepanova IP Fitzsimmons C 1997 H-0139 Effect of deoxycorticosterone acetate on blood pressure in relation to accumulation of low-density lipoprotein and fibrinogen by aorta and other tissues of normotensive Wistar rats. Medina RA Cardona-Sanclemente LE Brown MJ 1997 H-0139 Effect of captopril and losartan on blood pressure and accumulation of LDL and fibrinogen by aortic wall and other tissues in normotensive and hypertensive rats. Medina R Cardona-Sanclemente LE Brown MJ 2000 H-0139 Endothelial dysfunction accompanies a pro-oxidant, pro-diabetic challenge in the insulin resistant, obese Zucker rat in vivo. Laight DW Desai KM Anggard EE 1998 H-0139 Investigation of oxidant stress and vasodepression to glyceryl trinitrate in the obese Zucker rat in vivo. Laight DW Kengatharan KM Gopaul NK 1999 H-0139 Pro-oxidant challenge in vivo provokes the onset of NIDDM in the insulin resistant obese Zucker rat. Laight DW Desai KM Gopaul NK 1998 H-0139 Reactive oxygen species regulate macrophage scavenger receptor type I, but not type II, in the human monocytic cell line THP-1. De Kimpe SJ Anggard EE 1996 H-0139 Angiotensinogen in human essential hypertension. Lavender P Newell-Price J Kamdar S 1998 H-0139 Absence of linkage of the epithelial sodium channel to hypertension in black Caribbeans. Munroe PB Strautnieks SS Farrall M 1998 H-0139 Evaluation of the Angiotensinogen Locus in Human Essential Hypertension: A European Study. Brand E Chatelain N Keavney B 1997 H-0139 Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor. Kotanko P Binder A Tasker J 1998 H-0139 Protective effect on Leishmania major infection of migration inhibitory factor, TNF-alpha, and IFN-gamma administered orally via attenuated Salmonella typhimurium. Xu D McSorley SJ Tetley L 1998 H-0139 Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. Xu D Leung BP Hunter D 1998 H-0139 Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells. Xu D Leung BP Huang F 1999 H-0139 A proinflammatory role for IL-18 in rheumatoid arthritis [see comments] Gracie JA Forsey RJ Gilmour A 1999 H-0139 Inhibitors of poly (ADP-ribose) synthetase protect rat proximal tubular cells against oxidant stress. Cuzzocrea S Thiemermann C 2000 H-0139 Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Cuzzocrea S Brown PA Zacharowski K 2000 H-0139 Lipoteichoic acid induces delayed protection in the rat heart: a comparison with endotoxin. Zacharowski K Frank S Otto M 2000 H-0139 Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo. Zacharowski K Cuzzocrea S Otto M 1999 H-0139 Recombinant galectin-1 and its genetic delivery suppress collagen-induced arthritis via T cell apoptosis. Rabinovitch G Daly G Dreja H 1999 H-0139 Amelioration of collagen-induced arthritis and suppression of interferon-gamma, interleukin-12, and tumor necrosis factor alpha production by interferon-beta gene therapy. Triantaphyllopoulos KA Williams RO Tailor H 2000 H-0139 Gene therapy for chronic relapsing experimental allergic encephalomyelitis using cells expressing a novel soluble p75 dimeric TNF receptor. Croxford JL Triantaphyllopoulos KA Neve RM 1998 H-0139 Mutation of proline 211 reduces shedding of the human p75 TNF receptor. Herman C 1998 H-0139 Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonists: correlation with induction of heme oxygenase 1. Qureshi SS Willis D Willoughby DA 1996 H-0139 The role of vascular endothelial growth factor in a murine chronic granulomatous tissue air pouch model of angiogenesis. Appleton I Brown NJ Willis D 1997 H-0139 The depletion of substance P by diclofenac in the mouse. Papworth J Alam C Seed M 2000 H-0139 Cyclopentenone prostaglandins-new allies in the war on inflammation [news] Willoughby DA Moore AR 1999 H-0139 The expression of endothelin-1 and endothelin-converting enzyme-1 are independently regulated in bovine aortic endothelial cells. Barker S 1996 H-0139 The conformation of human big endothelin-1 favours endopeptidase hydrolysis of the TRP21-VAL22 bond. 2000 H-0139 Endothelin-2 synthesis is stimulated by the type-1 tumour necrosis factor receptor and cAMP: comparison with endothelin-converting enzyme-1 expression. Lambert GL Barker S Lees DM 1999 H-0139 Studies of the role of endothelium-dependent nitric oxide release in the sustained vasodilator effects of corticotrophin releasing factor and sauvagine. Barker DM 1997 H-0139 Tamoxifen inhibits the release of arachidonic acid stimulated by thapsigargin in estrogen receptor-negative A549 cells. Choudhury Q White JO Flower RJ 2000 H-0139 Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism [In Process Citation] Choudhury Q Flower RJ 1996 H-0139 The concerted regulation of cPLA2, COX2, and lipocortin 1 expression by IL-1beta in A549 cells. Newman SP Choudhury Q Flower RJ 1998 H-0139 Inhibitory effect of peptides derived from the N-terminus of lipocortin 1 on arachidonic acid release and proliferation in the A549 cell line: identification of E-Q-E-Y-V as a crucial component. Choudhury Q Flower RJ 1998 H-0139 Antibodies to beta2-glycoprotein I: a potential marker for clinical features of antiphospholipid antibody syndrome in patients with systemic lupus erythematosus. Sanfilippo SS Khamashta MA Atsumi T 1999 H-0139 Lymphocyte activation markers and von Willebrand factor antigen in Wegener's granulomatosis: potential markers for disease activity. Direskeneli H Khamashta M Hughes GVR 1997 H-0139 Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects. Szabo C Lim LH Cuzzocrea S 1999 H-0139 Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: role of intercellular adhesion molecule 1 and KC. Tailor A Tomlinson A Salas A 1997 H-0139 Lipocortin 1 protects against splanchnic artery occlusion and reperfusion injury by affecting neutrophil migration. Cuzzocrea S Tailor A Zingarelli B 1996 H-0139 Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1. Perretti M Ahluwalia A Harris JG 1998 H-0139 Evidence for a difference in nitric oxide biosynthesis between healthy women and men. Kneale BJ Milne E Chowienczyk PJ 1999 H-0139 Measurement of nitric oxide synthesis in humans using L-[15N2]arginine. Smith LM Milne E Benjamin N 1999 H-0139 Nitric oxide synthesis in patients with infective gastroenteritis. Dykhuizen RS Milne E McKenzie 1997 H-0139 Basal nitric oxide synthesis in essential hypertension [see comments] Copland M Smith LM Milne E 1997 H-0139 Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. Flower RJ Parente L De Medicis R 1997 H-0139 Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1. Flower RJ Perretti M 2000 H-0139 Natural and synthetic agonists of the melanocortin receptor type 3 possess anti inflammatory properties. Allcock GH Flower RJ Perretti M 1999 H-0139 POMC gene-derived peptides activate melanocortin type 3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. Gibbs L Clark AJ Flower RJ 1998 H-0139 Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation. Tomlinson A Willoughby DA 1999 H-0139 Inducible cyclooxygenase may have anti-inflammatory properties [see comments] Colville-Nash PR Willis D Chivers J 1998 H-0139 Differential effects of inhibition of isoforms of cyclooxygenase (COX-1, COX-2) in chronic inflammation [see comments] Tomlinson A Willoughby DA 2000 H-0139 Cell cycle dependent expression of cyclo-oxygenase 2 in human fibroblasts. Saunders MA Sansores-Garcia Wu KK 1999 H-0139 Immunotherapy of auto-immune diseases by gene transfer [In Process Citation] Chernajovsky Y Annenkov A Dreja H 2000 H-0139 A novel doxycycline inducible autoregulatory plasmid which displays 'on'/'off' regulation suited to gene therapy applications. Berenstein M Dreja H Ledda F 2000 H-0139 Immuno- and genetic therapy in autoimmune diseases. Chernajovsky Y Dreja H